Infiltration and sealing for managing non-cavitated proximal lesions: a systematic review and meta-analysis

Abstract Background Infiltration and sealing are micro-invasive treatments for arresting proximal non-cavitated caries lesions; however, their efficacies under different conditions remain unknown. This systematic review meta-analysis aimed to evaluate the caries-arresting effectiveness of infiltration further analyse across dentition types risk levels. Methods Six electronic databases were searched published literature, references manually searched. Split-mouth randomised controlled trials (RCTs) compare between infiltration/sealing non-invasive in lesions included. The primary outcome was obtained from radiographical readings. Results In total, 1033 citations identified, 17 RCTs (22 articles) reduced odds lesion progression (infiltration vs. non-invasive: OR = 0.21, 95% CI 0.15–0.30; placebo: 0.27, 0.18–0.42). For both permanent dentitions, more effective than (primary dentition: 0.30, 0.20–0.45; 0.20, 0.14–0.28). overall effects significantly control based on levels (OR Except at moderate (moderate risk: 0.32, 0.01–8.27), there significant differences (low 0.24, 0.08–0.72; low 0.38, 0.18–0.81; high 0.17, 0.10–0.29; 0.14, 0.07–0.28). superior 0.10–0.39; 0.05–0.37). Conclusion efficacious halting lesions.